Telomere, telomerase and telomerase inhibitors
نویسندگان
چکیده
منابع مشابه
Telomere and telomerase in hematologicalmalignancies.
INTRODUCTION In recent years, there has been a rapid increase in the number of researches on telomerase, since the definition of telomeres as the mitotic clock of the cell. Researchers are interested in the possible effects of telomeres and telomerase in carcinogenesis due to the relation between the telomeres and telomerase and the cell cycle. Telomere length alterations have been observed in ...
متن کاملTelomerase inhibitors.
There has been a vast increase in telomerase research over the past several years, with many different pre-clinical approaches being tested for inhibiting the activity of this enzyme as a novel therapeutic modality to treat malignancy. In this review, we will provide some basic background information about telomeres and telomerase and then discuss the pros, cons and challenges of the approaches...
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Telomeres are specialized structures at the ends of all eukaryotic chromosomes and have special biological functions. They protect chromosomes from nucleolytic degradation, endto-end fusions, and to be recognized as damaged DNA. Telomeres also contribute to the functional organizations of the chromosomes within the nucleus, participate in the regulation of gene expression, and most importantly,...
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Telomerase is a reverse transcriptase capable of utilizing an integrated RNA component as a template to add protective tandem telomeric single strand DNA repeats, TTAGGG, to the ends of chromosomes. Telomere dysfunction and telomerase reactivation are observed in approximately 90% of human cancers; hence, telomerase activation plays a unique role as a nearly universal step on the path to malign...
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Telomerase is an enzyme that maintains the length of the telomere. The telomere length specifies the number of divisions a cell can undergo before it finally dies (i.e. the proliferative potential of cells). For example, telomerase is activated in embryonic cell lines and the telomere length is maintained at a constant level; therefore, these cells have an unlimited fission potential. Stem cell...
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ژورنال
عنوان ژورنال: Bioorganic and Medicinal Chemistry Reports
سال: 2020
ISSN: 2667-6028
DOI: 10.25135/acg.bmcr.20.20.06.1686